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By Jim Phillips

Alpha-GPC: Clinically Proven to Increase Motivation

Whether you're looking to get motivated, boost cognitive function, or enhance physical performance, Alpha-GPC offers a fascinating avenue for exploration in the realm of brain health.

Understanding Alpha-GPC:

Alpha-GPC, or alpha-glycerylphosphorylcholine, is a natural compound that contains choline, a water-soluble essential nutrient. Choline is important for various bodily functions, including the production of the neurotransmitter acetylcholine, which plays a crucial role in cognitive function and memory.

Mechanistic evidence suggests that alpha-GPC exerts its effects by increasing the synthesis and release of acetylcholine in the brain, where it is involved in memory, motivation, arousal, and attention. 

Alpha-GPC provides several benefits for the brain. Here are some of the ways in which alpha-GPC impacts brain function:

Cognitive Benefits:

  1. Increased Acetylcholine Levels: By serving as a precursor to acetylcholine, Alpha-GPC is believed to boost neurotransmitter levels in the brain, potentially leading to improved cognitive processes, memory formation, and learning abilities.

  2. Increases Motivation: αGPC elicits feelings of increased motivation in human subjects, potentially through interaction with dopamine circuits in the brain.
  3. Neuroprotection: Some studies suggest that Alpha-GPC may have neuroprotective effects, helping to shield brain cells from damage and supporting overall brain health.
  4. Memory Enhancement: Research indicates that Alpha-GPC supplementation may positively impact memory, making it an attractive option for those seeking cognitive enhancement.

  5. Treatment for Cognitive Disorders: Research has explored the use of alpha-GPC in the treatment of various cognitive disorders, including Alzheimer's disease. Some studies show that alpha-GPC has a positive impact on cognitive function in individuals with certain neurological conditions.

Beyond the Brain: Physical Performance

While the primary focus of Alpha-GPC is often on cognitive benefits, it has also been studied for its potential to enhance physical performance. Athletes and bodybuilders may use it to support strength and power output during physical activities.

How Long Does it Take for Alpha-GPC to Kick In? 

Alpha-GPC increases acetylcholine levels almost immediately, so you can expect to feel the effects 20-30 minutes after ingestion. The effects of alpha-GPC last about four to six hours.

Further Reading on Increases in Motivation

  1. Yasuhisa Tamura, RIKEN Center for Biosystems Dynamics Research: Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study


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